1. Msgr. ALVAREZ, Jose O.P. 1904-1931 (Prefect Apostolic)
2. Msgr. DE LA HOZ, Thomas O.P. 1931-1935 (Prefect Apostolic)
3. Msgr. PEREZ, Modesto O.P. 1935-1940 (Prefect Apostolic)
4. Most Rev. TAGUCHI, Paul Yoshigoro 1941-1963 (Administrator Apostolic)
5. Most Rev. TANAKA, Francis Xavier Eikichi 1963-1977
6. Most Rev. FUKAHORI, Joseph Satoshi 1977-2004

The Prefecture Apostolic of Shikoku was established on January 27, 1904 when the four prefectures of Shikoku (Tokushima, Kochi, Kagawa, and Ehime) were separated from the Diocese of Osaka and entrusted to Spanish Dominicans of the Rosario Province. On February 26, 1904, Father Jose Alvarez, O.P. was appointed as the first prefect apostolic.

In 1931, when Monsignor Alvarez resigned because of illness, Monsignor Thomas de la Hoz, O.P. succeeded him as prefect apostolic. In 1935 Father Modesto Perez, O.P. was appointed. He resigned in 1940, and from 1941 Bishop Taguchi Yoshigoro of Osaka served concomitantly as administrator of the Prefecture Apostolic of Shikoku. In 1949, the prefect apostolic's residence was moved from Tokushima to Takamatsu.

On September 13, 1963, the Prefecture Apostolic of Shikoku was elevated to the status of a diocese and its name was changed to the Diocese of Takamatsu. On October 20 of that year Father Tanaka Eikichi was consecrated bishop and became the first Bishop of Takamatsu. Father Fukahori Satoshi was consecrated bishop on September 23, 1977 and took over as Bishop of Takamatsu.

On May 14, 2004, Bishop Fukahori resigned and Bishop Mizobe was appointed his successor Bishop Mizobe was installed on July 19, 2004.